QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is Retatrutide??
Retatrutide (LY3437943, CAS 2381932-72-3) is a 39-amino acid triple-receptor agonist simultaneously activating the GIP receptor (GIPR), GLP-1 receptor (GLP-1R), and glucagon receptor (GCGR) — the first clinically investigated triagonist incretin peptide. Developed by Eli Lilly, it incorporates a C18 fatty diacid moiety for albumin binding, yielding a half-life of approximately 6 days. Phase 2 data demonstrated up to ~24% body weight reduction — exceeding tirzepatide (dual GIP/GLP-1) — primarily attributed to the additive glucagon receptor arm driving hepatic fat oxidation, thermogenesis, and appetite suppression independent of insulin secretion. Retatrutide is the leading research tool for dissecting the individual and combined contributions of all three incretin-related receptor axes.
Research Applications
Triple Receptor Dissection
GIPR vs. GLP-1R vs. GCGR individual arm contributions — selective antagonist co-treatment designs
Obesity & Thermogenesis
GCGR-mediated energy expenditure, brown adipose UCP1, hepatic fat oxidation — beyond dual incretin
Glucose Homeostasis
Triple incretin insulin secretion, glucagon regulation balance, hepatic glucose output at GCGR
NAFLD/NASH Research
Hepatic steatosis, liver fat quantification, fibrosis biomarkers under triple agonism
vs Tirzepatide Comparison
Dual (tirzepatide) vs. triple (retatrutide) incretin: weight loss depth, metabolic breadth, receptor kinetics
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 2381932-72-3 |
| Also Known As | LY3437943, triple incretin agonist |
| Molecular Weight | ~4681 Da |
| Half-Life | ~6 days (C18 fatty diacid albumin binding) |
| Receptors | GIPR + GLP-1R + GCGR (triple agonist) |
| Peptide Type | Synthetic triple incretin receptor agonist — triagonist |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
