QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is Thymosin Alpha-1??
Thymosin Alpha-1 (Tα1, CAS 62304-98-7) is a 28-amino acid acetylated N-terminal fragment of prothymosin alpha, first isolated from thymic tissue. Molecular formula C₁₂₉H₂₁₅N₃₃O₅₅, MW 3108.3 g/mol. Tα1 acts on toll-like receptors (TLR2, TLR9) and the STING pathway to upregulate dendritic cell maturation, Th1 cytokine production (IFN-α/γ, IL-2, IL-12), and NK cell activity. It also potentiates vaccine responses and supports T-cell differentiation from thymic precursors — making it the cornerstone research tool for innate/adaptive immune interface studies.
Research Applications
Innate Immune Activation
TLR2/TLR9/STING agonism, dendritic cell maturation, IFN-α/γ production, NF-κB signalling
T-Cell Immunity
Th1 polarisation (IL-2, IL-12), thymopoiesis, CD4+/CD8+ T-cell differentiation, MHC upregulation
NK Cell Function
NK cell cytotoxicity enhancement, NKG2D expression, ADCC potentiation
Vaccine Adjuvancy
Antigen-specific antibody titers, memory T-cell formation, checkpoint expression profiling
Immunodeficiency & Sepsis Models
T-cell exhaustion reversal, innate immune restoration, sepsis immune paralysis models
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 62304-98-7 |
| Molecular Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Weight | 3108.3 g/mol |
| Peptide Type | Synthetic thymic peptide / TLR/STING immune modulator |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
