QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is TB-500??
TB-500 (Thymosin Beta-4, Tβ4, CAS 77591-33-4) is a synthetic version of the endogenous 43-amino acid actin-sequestering peptide present in virtually all mammalian cells. Molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S, MW 4963.5 g/mol. Tβ4 promotes actin polymerisation dynamics critical to cell migration and wound closure, upregulates matrix metalloproteinases, stimulates angiogenesis via VEGF/SDF-1 pathway upregulation, and has anti-inflammatory activity through NF-κB and actin-MRTF-SRF pathway modulation. It is one of the most thoroughly investigated peptides in tissue repair and cardiac regeneration research.
Research Applications
Actin Dynamics & Cell Migration
G-actin sequestration, treadmilling regulation, lamellipodia formation, wound closure models
Angiogenesis
VEGF, SDF-1, MMP upregulation, endothelial tube formation, ischaemia-driven vessel growth
Cardiac Regeneration
Cardiomyocyte survival after MI, epicardial progenitor activation, cardiac remodelling models
Anti-Inflammation
NF-κB pathway modulation, IL-6/TNF-α reduction, macrophage M2 polarisation
Tendon & Muscle Repair
Tenocyte migration, skeletal muscle satellite cell activation, fibrosis reduction
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 77591-33-4 |
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | 4963.5 g/mol |
| Peptide Type | Endogenous actin-sequestering peptide / tissue repair agent |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
