PE-22-28 10mg | 20-Vial Kit | Progerin-Targeting

QSC PE-22-28 (Spadin analog, TREK-1 blocker) — ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.

✓ 99%+ Purity ✓ COA Available
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$360

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SKU: QSC-PE2228-10MG-20VIAL
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QSC RESEARCH GRADE

≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping

What is PE-22-28?

PE-22-28 (Spadin analog — TREK-1 potassium channel blocker) is a 7-amino acid synthetic spadin-derived peptide. Synthetic spadin-derived peptide blocking the TREK-1 (TRAAK-related potassium channel-1) two-pore-domain K⁺ channel, which is overexpressed in depression models and reduces neuronal excitability. TREK-1 blockade increases firing rate and serotonin release — antidepressant mechanism without SSRI profile or sedation.

Research Applications

TREK-1 Channel Pharmacology

Two-pore-domain K⁺ channel block — neuronal excitability increase

Antidepressant Biology

Depression model research without SSRI target or sedation

Sortilin/Spadin Axis

Sortilin propeptide biology, TREK-1 regulation mechanism

Serotonin Release

5-HT release augmentation via neuronal depolarisation

Ion Channel Research

K⁺ channel pharmacology, membrane potential, firing rate studies

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number Not publicly standardized
Molecular Formula Sequence-dependent (7-amino-acid peptide)
Peptide Type Synthetic Peptide / Progerin-Targeting Fragment
Identity MS molecular weight confirmed — every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (2–4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

🧪 Peptide Research Tools: Use QSC’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA  ·  🇪🇺 EU  ·  🇬🇧 UK  ·  🇨🇦 Canada  ·  🇦🇺 Australia
🧬 PubMed Research — 10mg
Search PubMed ↗

Source: PubMed / NCBI  ·  Last 10 years  ·  Refreshed every 24 hours  ·  For research reference only — not clinical guidance.

⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION

QSC products are strictly for in vitro and in vivo laboratory research. Not intended for diagnostic, therapeutic, or personal use.

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Research Use Disclaimer

All QSC products are strictly for laboratory, scientific, and research use only. They are not for human consumption, medical treatment, diagnosis, or disease prevention.

By purchasing or using QSC products, you confirm:

  • You are a qualified researcher or acting under the supervision of one.
  • Products will only be used for legitimate research purposes.
  • Products are not evaluated by the FDA or any regulatory authority for human use.
  • You assume all responsibility for legal compliance, proper handling, and storage.
  • You meet the legal age requirement in your jurisdiction.
No Warranty: Products are sold “as is,” with no express or implied warranties regarding efficacy, safety, or suitability. Results in research may vary. QSC is not responsible for outcomes, interpretations, or conclusions drawn from any studies conducted using these products.
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General Safety & Handling

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Not for Human Use

These compounds are for research only. Any off-label, personal, or clinical use is strictly outside the intended scope of supply.

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PPE Required

Always use appropriate personal protective equipment (gloves, lab coat, eye protection) when handling peptides.

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Storage Compliance

Follow product-specific storage conditions to maintain identity, purity, and biological activity.

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Proper Disposal

Dispose of all materials in accordance with institutional biosafety, chemical waste, and hazardous material protocols.

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Verify Quality

Janoshik COAs are available on every product page. Verify batch identity (MS confirmed) and purity (≥99% HPLC) before use.

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Peptide Storage Guidelines

🌑 Light-protected💧 Low moisture🌡️ Stable temperature🔬 Sterile handling

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