QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is Orexin B (High-Dose)??
Orexin B (Hypocretin-2, CAS 205640-91-1) is a 28-amino acid OX2R-selective hypothalamic neuropeptide. This 10mg/vial high-dose format supports research protocols requiring larger quantities – dose-escalation OX2R receptor occupancy studies, multi-cohort sleep paradigms, high-throughput competitive binding assays, or extended in vivo infusion experiments investigating OX2R-mediated histaminergic arousal, sleep-wake architecture, or suvorexant mechanism-of-action comparisons. The 10mg format also enables combination assays comparing Orexin B (OX2R-selective) vs. Orexin A (OX1R/OX2R dual) biology side-by-side with adequate quantities for both arms.
Research Applications
High-Dose OX2R Occupancy
Dose-escalation receptor saturation kinetics, Bmax/Kd determination in hypothalamic membrane preparations
Multi-Cohort Sleep Studies
Sufficient for large-animal or multi-arm sleep EEG studies requiring repeated orexin B administration
High-Throughput Receptor Screening
Competitive binding assays – Orexin B as OX2R radioligand competitor against novel antagonist libraries
Suvorexant Mechanism Studies
OX2R occupancy correlation with sleep onset/maintenance – comparison with dual OX1R/OX2R blockade
Comparative Orexin Biology
Orexin A vs. B functional comparison assay – OX1R-specific phenotypes vs. OX2R-specific phenotypes with 10mg of each
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| CAS Number | 205640-91-1 |
| Also Known As | Hypocretin-2, HCRT2 |
| Sequence | Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| Receptor Selectivity | OX2R-preferring (~5-100x vs. OX1R) – 10mg/vial high-dose |
| Peptide Type | Endogenous 28-aa hypothalamic neuropeptide / OX2R-selective agonist – high dose |
| Identity | MS molecular weight confirmed – every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Shelf Life | 24 months unopened |
