QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is MGF??
MGF (Mechano Growth Factor) is a splice variant of IGF-1 (the Ec isoform in humans, CAS 87081-35-4) produced locally in muscle tissue in response to mechanical loading or damage. The unique E-domain peptide (24 aa) of MGF activates satellite cell proliferation independently of the IGF-1 receptor — acting through a distinct receptor population to expand the myoblast pool before differentiation. After local depletion (~minutes), circulating systemic IGF-1 drives differentiation and protein synthesis. PEGylated MGF extends this half-life significantly for sustained research models.
Research Applications
Satellite Cell Activation
Muscle stem cell proliferation, E-domain receptor signalling, post-injury myoblast pool expansion
Mechano-Transduction
Mechanical loading → MGF splice induction, IGF-1Ec vs. IGF-1Ea isoform comparison
Muscle Repair Models
Eccentric contraction injury, muscle wasting (cachexia, sarcopenia), re-innervation models
IGF-1 Axis Dissection
MGF vs. systemic IGF-1 temporal sequencing, E-domain vs. IGF-1R activation
Neuroprotection
MGF E-domain peptide neuroprotective effects in motor neuron and cortical neuron models
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 87081-35-4 |
| Also Known As | IGF-1 Ec splice variant, Mechano-IGF-1 |
| Peptide Type | Synthetic IGF-1 splice variant / muscle satellite cell activator |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
