QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS1-Region Domestic Shipping
What is KPV?
KPV (Lys-Pro-Val) is the biologically active C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH). Despite lacking the melanotropic N-terminal region of α-MSH, KPV retains potent anti-inflammatory activity — acting via MC1R and intracellular mechanisms to suppress NF-κB activation, reduce pro-inflammatory cytokine production, and protect intestinal epithelial barrier integrity. Research use only.
Research Applications
MC1R Anti-Inflammatory Signalling
Receptor-mediated cAMP elevation, NF-κB suppression, cytokine modulation
Intestinal Inflammation Research
Gut epithelial barrier protection, IBD models, tight junction preservation
Intracellular Anti-Inflammatory
Direct nuclear NF-κB inhibition independent of surface receptor — dual mechanism
Skin & Wound Inflammation
Dermal anti-inflammatory activity, keratinocyte cytokine suppression, wound healing
Comparative α-MSH Research
KPV tripeptide vs full-length α-MSH and Melanotan II — receptor selectivity
Quick Specs
| Form | Tablet — 500mcg per tablet, 100-tablet bottle |
| CAS Number | 69661-79-6 |
| Molecular Formula | C₁₅H₂₈N₄O₅ |
| Molecular Weight | 344.4 g/mol |
| Compound Type | α-MSH C-Terminal Tripeptide / MC1R Anti-Inflammatory |
| Purity | ≥99% by HPLC — every batch |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house synthesis — Qingdao, China |
| Storage | Room temperature sealed | cool, dry storage |
| Shelf Life | 24 months unopened |
