QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is HGH Fragment 176-191??
HGH Fragment 176-191 (CAS 66004-57-7) is the C-terminal amino acid sequence 176–191 of the 191-amino acid human growth hormone molecule. Molecular formula C₇₈H₁₂₃N₂₃O₂₃S₂, MW 1,817.12 g/mol. Unlike full HGH, this fragment retains the lipolytic (fat-burning) activity of growth hormone without binding the GH receptor or stimulating IGF-1 production — making it a research tool for studying adipocyte lipolysis mechanisms that are independent of the GH/IGF-1 axis. In rodent models it has demonstrated increased lipolysis in white adipose tissue and reduced hyperglycaemia.
Research Applications
Adipocyte Lipolysis
β-adrenergic/cAMP-independent fat mobilisation pathway, hormone-sensitive lipase activation
HGH Bioactivity Mapping
Fragment vs. full-length HGH functional dissection — lipolytic domain without GHR binding
Carbohydrate Metabolism
Glucose regulation and anti-hyperglycaemic effects independent of IGF-1 induction
Fat Depot Selectivity
Visceral vs. subcutaneous adipose tissue lipolysis differential studies
GH Axis Comparison
HGH Fragment 176-191 vs. intact HGH vs. GHRH analogs — IGF-1 independence profiling
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 66004-57-7 |
| Sequence | HGH aa 176–191 C-terminal fragment |
| Molecular Formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| Molecular Weight | 1817.12 g/mol |
| Peptide Type | Synthetic GH C-terminal fragment / lipolytic peptide — IGF-1 independent |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
