QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is Dulaglutide (High-Dose)??
Dulaglutide (LY2189265, CAS 923950-08-7) is a ~63 kDa IgG4-Fc homodimeric GLP-1 receptor agonist with a ~5-day half-life. This 10mg/vial high-dose format is designed for dose-escalation studies, multi-cohort metabolic experiments, severe obesity models, or sustained GLP-1R stimulation protocols requiring larger quantities. It enables investigation of supraphysiological GLP-1R activation — receptor downregulation kinetics, tachyphylaxis, high-dose cardiovascular effects, and β-cell exhaustion prevention vs. stimulation.
Research Applications
High-Dose GLP-1R Activation
Supraphysiological receptor occupancy, cAMP saturation kinetics, β-arrestin recruitment at high doses
Severe Obesity Models
High-fat diet / leptin-deficient mouse models, dose-escalation weight loss mechanisms
β-Cell Mass Studies
Sustained GLP-1R stimulation effects on β-cell proliferation, apoptosis, and mass — long-term models
Receptor Downregulation
GLP-1R internalisation, recycling, tachyphylaxis mechanisms at elevated dulaglutide concentrations
Cardiovascular Research
High-dose GLP-1R cardioprotection — atherosclerosis, heart failure, and inflammation models
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 923950-08-7 |
| Also Known As | LY2189265, Trulicity® active peptide |
| Molecular Weight | ~63 kDa (IgG4-Fc homodimer) |
| Half-Life | ~5 days (IgG4-Fc mediated) — 10mg/vial high-dose |
| Peptide Type | Long-acting GLP-1R agonist Fc-fusion protein — high dose |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
