QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is Dihexa (High-Dose)??
Dihexa (PNB-0408, CAS 1239264-98-2) is a highly CNS-penetrant HGF/MET-potentiating peptidomimetic that drives de novo synaptogenesis — estimated at 10⁷-fold greater potency than BDNF for new dendritic spine formation. This 10mg/vial high-dose format supports dose-escalation protocols, multi-cohort neurodegeneration studies, transdermal delivery experiments, and long-duration cognitive paradigms where larger quantities per session are required. Molecular formula C₂₄H₃₉N₃O₄, MW 437.58 g/mol.
Research Applications
High-Dose Synaptogenesis
Dose-escalation dendritic spine density, concentration-response at HGF/MET receptor
Extended Cognitive Studies
Multi-week spatial learning, fear conditioning, and NOR paradigms requiring higher peptide reserves
Transdermal Delivery Research
Lipophilicity-driven skin penetration studies, bioavailability comparison vs. sc/ip routes
Neurodegeneration Reversal
High-dose Alzheimer’s-model synapse recovery, AChE-lesion and Aβ model synaptogenesis restoration
Neuroplasticity Mechanisms
LTP, AMPA/NMDA receptor trafficking, PSD-95 clustering under sustained HGF/MET activation
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 1239264-98-2 |
| Also Known As | PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide |
| Molecular Formula | C₂₄H₃₉N₃O₄ |
| Molecular Weight | 437.58 g/mol |
| Mechanism | HGF/MET receptor complex potentiation → synaptogenesis — 10mg/vial high-dose |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |

