QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is Dermorphin??
Dermorphin (CAS 77614-16-5) is a naturally occurring heptapeptide opioid first isolated from the skin of South American frogs (Phyllomedusa sauvagei). Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂. Molecular formula C₄₀H₅₀N₈O₁₀, MW 802.88 g/mol. Notably, it contains a D-alanine residue at position 2 — rare in vertebrate peptides — which confers resistance to enzymatic degradation. Dermorphin has approximately 1,000-fold greater potency at µ-opioid receptors (MOR) than morphine in preclinical binding assays, with high selectivity for MOR over δ and κ receptors. It is a fundamental research tool for opioid receptor pharmacology.
Research Applications
µ-Opioid Receptor Pharmacology
MOR binding affinity, Gi/o signalling, receptor selectivity vs. DOR/KOR profiling
Opioid Analgesia Research
Central and peripheral analgesic mechanisms, tolerance and sensitisation models
D-Amino Acid Stability
Enzymatic resistance studies — D-Ala² contribution to DPP-IV and protease stability
Receptor Signalling
cAMP suppression, GIRK channel activation, β-arrestin bias studies
Comparative Opioid Studies
Potency ratio comparisons with morphine, DAMGO, and endomorphins
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 77614-16-5 |
| Sequence | H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂ |
| Molecular Formula | C₄₀H₅₀N₈O₁₀ |
| Molecular Weight | 802.88 g/mol |
| Peptide Type | Natural heptapeptide opioid / µ-MOR selective agonist |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
