QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is AICAR??
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide, also known as Acadesine or AICA Ribonucleotide, CAS 2627-69-2) is a cell-permeable nucleoside analogue that is phosphorylated intracellularly to ZMP — a structural AMP mimic. Molecular formula C₉H₁₄N₄O₈P, MW 338.21 g/mol (free acid). ZMP directly activates AMP-activated protein kinase (AMPK) by allosterically mimicking a rise in cellular AMP:ATP ratio, without requiring actual energy depletion. As an exercise-mimetic compound, AICAR recapitulates key molecular adaptations of endurance exercise — upregulating GLUT4, stimulating fatty acid oxidation, inducing mitochondrial biogenesis via PGC-1α, and activating SIRT1. It is the gold-standard research tool for dissecting AMPK-dependent from AMPK-independent exercise signalling.
Research Applications
AMPK Activation
Direct ZMP-mediated AMPK allosteric activation, Thr172 phosphorylation, α1/α2 subunit isoform specificity
Exercise-Mimetic Biology
GLUT4 translocation, skeletal muscle glucose uptake independent of insulin — endurance training model
Mitochondrial Biogenesis
PGC-1α/SIRT1/NRF1 axis, mtDNA copy number, cytochrome c oxidase and citrate synthase induction
Fatty Acid Oxidation
ACC phosphorylation → malonyl-CoA reduction → CPT-1 disinhibition → β-oxidation upregulation
Cardioprotection & Longevity
Ischaemic preconditioning, mTORC1 inhibition, autophagy induction, AMPK-mediated anti-ageing pathways
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 2627-69-2 |
| Also Known As | Acadesine, AICA Ribonucleotide, ZMP precursor |
| Molecular Formula | C₉H₁₄N₄O₈P |
| Molecular Weight | 338.21 g/mol (free acid) |
| Mechanism | Intracellular phosphorylation → ZMP → AMPK Thr172 allosteric activation |
| Peptide Type | Nucleoside analogue / AMPK activator — exercise-mimetic |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
