QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is GHK-Cu?
GHK-Cu (Glycyl-L-histidyl-L-lysine copper(II) complex) is a Copper-binding tripeptide. Naturally occurring copper tripeptide that activates fibroblasts to upregulate collagen I/III/IV and elastin synthesis, inhibits MMP-1/2/9 collagen degradation enzymes, activates lysyl oxidase for collagen cross-linking, stimulates wound bed angiogenesis via VEGF/FGF-2, and activates Nrf2 antioxidant response element genes. Plasma concentration declines ~60% with ageing.
Research Applications
Collagen Synthesis
Fibroblast activation — collagen types I, III, IV gene upregulation
MMP Inhibition
MMP-1/2/9 inhibition — protects newly synthesised ECM from degradation
Cross-linking
Lysyl oxidase (copper-dependent) activation — tensile strength
Wound Angiogenesis
VEGF/FGF-2 upregulation, neovascularisation in wound bed
Nrf2 Antioxidant
Antioxidant gene expression — SOD, catalase, HO-1 upregulation
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 89030-95-5 |
| Molecular Formula | C₁₄H₂₄CuN₆O₄ |
| Peptide Type | Copper-Binding Tripeptide / Regenerative Signaling Peptide |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
