QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COA5-Region Domestic Shipping
What is 5-Amino-1MQ 5mg?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). By blocking NNMT, it prevents the methylation and disposal of nicotinamide, raising intracellular NAD+ levels and activating SIRT1-mediated fat oxidation. Research applications include obesity, metabolic syndrome, and adipocyte biology.
Research Applications
Fat Oxidation & Adipocyte Research
NNMT inhibition reduces adipogenesis and promotes lipolysis in white adipose tissue. 3T3-L1 cell model standard for evaluating anti-obesity activity.
NAD+ / SIRT1 Pathway Research
Raising intracellular NAD+ activates sirtuins (SIRT1, SIRT3) — links to longevity, mitochondrial biogenesis, and glucose metabolism pathways.
Metabolic Syndrome Models
DIO mouse models: 5-Amino-1MQ reduces fat mass and improves insulin sensitivity without affecting food intake — distinct from appetite-suppression mechanisms.
Quick Specs
| Product | 5-Amino-1MQ 5mg × 10 Vials (50mg total) |
| CAS | 1342278-01-6 |
| Format | Lyophilised powder, 10-vial kit |
| Purity | ≥99% HPLC, MS confirmed |
| Storage | −20°C lyophilised; 4°C reconstituted, 7 days |
| Reconstitution | Bacteriostatic water or DMSO |
