Humanin is a 21-amino acid mitochondrial-derived peptide (MDP) β one of the first discovered mitochondrial peptides encoded not by nuclear DNA but within the 16S ribosomal RNA region of the mitochondrial genome itself. It was identified by Hashimoto et al. (2001) through a screen for factors protecting neurons from Alzheimer’s disease-related amyloid toxicity.
Humanin acts through two receptor systems: FPRL2 (formyl peptide receptor-like 2) for its anti-apoptotic effects, and the gp130/IL-6RΞ±/CNTFR trimeric receptor complex for broader cytoprotective and STAT3-mediated signalling. It also modulates the IGF-1/IGFBP-3 axis β binding IGFBP-3 and altering insulin-like signalling in ways that support metabolic research applications beyond neuroprotection.
Specifications
Compound
Humanin
Sequence Length
21 amino acids
Origin
Mitochondrial genome (16S rRNA region)
Primary Receptors
FPRL2, gp130/IL-6RΞ±
Downstream Signalling
STAT3 phosphorylation, anti-apoptotic pathway
QSC Purity
β₯99% HPLC Β· MS confirmed Β· Janoshik COA
Shipping
US Domestic: 2β4 days Β· International: 5β14 days
Frequently Asked Questions
What is humanin?
Humanin is a 21-amino acid mitochondrial-derived peptide (MDP) encoded within the 16S ribosomal RNA region of the mitochondrial genome. It was first identified as a neuroprotective factor in Alzheimer’s disease models. Humanin acts via FPRL2 (formyl peptide receptor-like 2) and the gp130/IL-6 receptor complex, activating STAT3 signalling and mitochondrial-nuclear retrograde communication.
What does humanin do?
Humanin activates cytoprotective signalling: STAT3 phosphorylation (via gp130), FPRL2-mediated anti-apoptotic pathways, mitochondrial membrane potential stabilisation, and suppression of amyloid-beta toxicity. Research applications include neuroprotection, Alzheimer’s disease models, insulin sensitisation (IGFBP-3 axis), and mitochondrial biology.
Where can I buy research-grade humanin?
QSC (qsc-usa.com) stocks research-grade humanin at β₯99% HPLC purity with Janoshik COA. Ships from US Domestic Warehouse in 2β4 business days. Sold for in vitro laboratory research only.
How does humanin relate to longevity research?
Humanin levels decline with age and are inversely correlated with age-related disease burden in human studies. Centenarian offspring show higher humanin levels. It is a key biomarker and research target in longevity biology β particularly in mitochondrial-nuclear communication and insulin/IGF-1 signalling crosstalk.
Buy Research-Grade Humanin
β₯99% HPLC Β· Janoshik COA Β· US Domestic 2β4 Days Β· Research Use Only
Research Use Only: Humanin is sold by QSC strictly for in vitro laboratory research. Not for human or veterinary use. Not FDA approved for clinical application.
