Clomiphene citrate is a SERM that competitively antagonises oestrogen receptors in the hypothalamus and pituitary. Blockade of negative feedback increases GnRH pulse frequency, driving LH and FSH release from the anterior pituitary. Elevated LH stimulates Leydig cell testosterone synthesis; elevated FSH stimulates Sertoli cells and spermatogenesis. Used in research models of hypothalamic-pituitary-gonadal (HPG) axis restoration, male hypogonadism, and fertility.
Also Known As
Clomiphene, Clomifene, Serophene
Compound Class
Selective Oestrogen Receptor Modulator (SERM)
Molecular Formula
C₂₆H₂₈ClNO
Molecular Weight
405.96 Da
CAS Number
50-41-9
Half-Life
~5–7 days
Research Applications
HPG Axis Restoration Research
Clomiphene is the reference compound for HPG axis reactivation research. Models: post-cycle suppression in rodents, idiopathic hypogonadotropic hypogonadism in men, hypothalamic amenorrhoea in women. LH/FSH/testosterone recovery kinetics well-characterised across species.
Male Hypogonadism / TRT Alternative
Phase 3 RCT data in men with secondary hypogonadism: clomiphene 25–50mg raises total testosterone to eugonadal range while preserving spermatogenesis (unlike exogenous testosterone). Key research model for fertility-preserving testosterone restoration.
Spermatogenesis Research
FSH elevation from clomiphene directly stimulates Sertoli cell-mediated spermatogenesis. Used in male infertility research models — oligospermia, azoospermia secondary to HPG suppression. Quantified via sperm count, motility, morphology readouts.
Ovulation Induction Research
Historically the first-line ovulation induction agent in women with anovulatory infertility (PCOS model). Hypothalamic ER blockade increases GnRH/LH pulsatility. Rodent and primate folliculogenesis models well-established.
Key Research Data
Study / Source
Key Findings
Katz et al. 2012 BJU Int
RCT in hypogonadal men: clomiphene 50mg raised T from 247 to 610 ng/dL, LH and FSH normalised, sperm parameters maintained
Whitten et al. 2013 Fertil Steril
Long-term clomiphene in hypogonadal men: sustained testosterone elevation, maintained spermatogenesis at 12 months
Purvin 1995 / Adverse data
Visual disturbance AEs documented — relevant for complete adverse event profiling in research models
Specifications
Format
Oral tablet — 50mg per tablet
Purity
≥99% HPLC
Identity
MS confirmed
Storage
Room temperature, protect from light
Class
SERM — not an androgen or AI
Frequently Asked Questions
What is Clomid (Clomiphene Citrate)?
Clomid (Clomiphene Citrate) is a Selective Oestrogen Receptor Modulator (SERM). Clomiphene citrate is a SERM that competitively antagonises oestrogen receptors in the hypothalamus and pituitary. Blockade of negative feedback increases GnRH pulse frequency, driving LH and FSH release from the anterior pituitary. Elevated LH stimu…
How does Clomid work in research models?
Clomiphene is the reference compound for HPG axis reactivation research. Models: post-cycle suppression in rodents, idiopathic hypogonadotropic hypogonadism in men, hypothalamic amenorrhoea in women. LH/FSH/testosterone recovery kinetics well-characterised across species….
What makes Clomid different from similar compounds?
Phase 3 RCT data in men with secondary hypogonadism: clomiphene 25–50mg raises total testosterone to eugonadal range while preserving spermatogenesis (unlike exogenous testosterone). Key research model for fertility-preserving testosterone restoration….
Does QSC ship Clomid to the USA?
Yes. QSC Clomid ships domestically across the USA and internationally to EU, UK, Canada, and Australia. Every batch carries a Janoshik third-party COA confirming ≥99% HPLC purity and MS identity verification.
