BAM15 is a novel mitochondrial protonophore uncoupler that dissipates the proton gradient across the inner mitochondrial membrane — increasing oxygen consumption and thermogenesis without hyperthermia. Unlike DNP (2,4-dinitrophenol), BAM15 does not collapse the plasma membrane potential, making it the first protonophore to uncouple mitochondria selectively without the acute toxicity associated with classical protonophores. Mechanism: proton shuttle across the IMM → reduced ATP synthesis efficiency → increased fatty acid oxidation to compensate → weight loss without diet restriction in DIO models. Critical advance: effective dose does not cause hyperthermia in mouse studies, addressing the principal safety concern of earlier uncouplers.
Also Known As
BAM15, protonophore uncoupler, BAM-15
Compound Class
Mitochondrial protonophore uncoupler — novel class
Molecular Formula
C₁₂H₉F₆N₃O
Molecular Weight
325.21 Da
CAS Number
1955981-47-3
Half-Life
Not fully characterised — active research compound
Research Applications
Mitochondrial Uncoupling Without Hyperthermia
BAM15 demonstrated effective uncoupling in C57BL/6 DIO mice with no increase in core body temperature at doses that reduced fat mass — the defining advantage vs DNP and earlier protonophores. Mechanism investigation: IMM selectivity, plasma membrane potential preservation.
Fat Mass / Metabolic Research
DIO mouse: BAM15 reduced fat mass, improved insulin sensitivity, reduced inflammation markers (IL-6, MCP-1) — metabolic improvements beyond weight loss alone. First-in-class data for mitochondrial uncoupler without thermal liability.
Insulin Resistance / Metabolic Syndrome
Uncoupling-driven fatty acid oxidation reduces intramyocellular lipid, improving insulin receptor signalling. BAM15 improved glucose tolerance and insulin sensitivity in DIO models independent of caloric restriction.
Drug Development / Protonophore Selectivity Research
BAM15 is the primary research tool for investigating selective mitochondrial uncoupling pharmacology — distinguishing IMM uncoupling from plasma membrane depolarisation. Reference compound for next-generation uncoupler development.
Key Research Data
Study
Key Findings
Kenwood et al. 2014 Mol Metab
BAM15 in DIO mice: fat mass reduction, no hyperthermia, insulin sensitivity improvement — foundational study
Kalinovich et al. 2016 Sci Rep
Protonophore selectivity: BAM15 vs FCCP vs DNP — membrane potential profiles across compartments
IMM-selective — no plasma membrane depolarisation, no hyperthermia at effective dose
FAQ
What is BAM15 (Mitochondrial Uncoupler)?
BAM15 (Mitochondrial Uncoupler) is a Mitochondrial protonophore uncoupler — novel class. BAM15 is a novel mitochondrial protonophore uncoupler that dissipates the proton gradient across the inner mitochondrial membrane — increasing oxygen consumption and thermogenesis without hyperthermia. Unlike DNP (2,4-dinitrophenol), BAM15 does not collapse th…
What research applications does BAM15 support?
BAM15 demonstrated effective uncoupling in C57BL/6 DIO mice with no increase in core body temperature at doses that reduced fat mass — the defining advantage vs DNP and earlier protonophores. Mechanism investigation: IMM selectivity, plasma membrane potential preservation….
How does BAM15 compare to similar compounds?
DIO mouse: BAM15 reduced fat mass, improved insulin sensitivity, reduced inflammation markers (IL-6, MCP-1) — metabolic improvements beyond weight loss alone. First-in-class data for mitochondrial uncoupler without thermal liability….
Does QSC ship BAM15 to the USA?
Yes. QSC ships domestically across the USA and to EU, UK, Canada, and Australia. Every batch carries a Janoshik third-party COA confirming ≥99% HPLC purity and MS identity.
