P21-adamantane 10mg | 10-Vial Kit | CNTF Nootropic Peptide

P21-adamantane 10mg | 10-Vial Kit | Adamantane-modified CNTF-derived peptide — hippocampal neurogenesis, BDNF upregulation, and cognitive research. ≥99% HPLC purity, Janoshik COA. Research use only.

✓ 99%+ Purity ✓ COA Available
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$420

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SKU: QSC-PP10-P21ADAMANTANE-10MG-10VIAL
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QSC RESEARCH GRADE

≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPSChina Warehouse

What is P21-adamantane?

P21-adamantane is a modified neurotrophin-mimetic peptide derived from the CNTF (ciliary neurotrophic factor) sequence, with an adamantane moiety attached to enhance blood-brain barrier penetration and receptor engagement. Activates STAT3/JAK signalling and BDNF expression. Studied for hippocampal neurogenesis, cognitive enhancement, and neuroprotection models, with the adamantane modification providing superior CNS bioavailability compared to unmodified P21. Research use only.

Research Applications

Hippocampal Neurogenesis

Dentate gyrus progenitor cell proliferation, BrdU/EdU incorporation, DCX expression

BDNF Upregulation

BDNF mRNA and protein expression, TrkB signalling, CREB phosphorylation

STAT3/JAK Pathway Research

CNTF receptor complex activation, STAT3 nuclear translocation, target gene profiles

Blood-Brain Barrier Penetration

Adamantane moiety CNS uptake vs unmodified peptide — pharmacokinetic comparison

Cognitive & Memory Research

Morris water maze, novel object recognition, LTP modulation in rodent models

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number 2411025-13-3
Molecular Formula Adamantane-AEAEAAAKEAAAKAAE (modified CNTF loop), MW ~2,200 Da
Identity MS molecular weight confirmed — every batch
Peptide Type CNTF-Derived Nootropic / Neurogenic Peptide
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (3 weeks)
Shelf Life 24 months (unopened)

Certificate of Analysis (COA)

For the latest Certificate of Analysis (COA), please email us with your request.

Frequently Asked Questions

How do I reconstitute P21-adamantane?
Add 1 mL bacteriostatic water to the lyophilized vial, directing liquid down the inner wall. Swirl gently until clear — takes 2–3 minutes due to the hydrophobic adamantane modification. Slight warming to 37°C can aid dissolution if needed.
How should P21-adamantane be stored?
Store lyophilized vials at −20°C. Reconstituted solution is stable at 2–8°C for up to 3 weeks. The adamantane moiety is susceptible to aggregation at high concentrations — avoid freeze-thaw cycling.
What is the significance of the adamantane modification in P21?
Adamantane is a lipophilic cage molecule that dramatically improves CNS penetration by facilitating passage through the blood-brain barrier. P21-adamantane shows superior hippocampal BDNF upregulation and neurogenesis compared to the unmodified P21 peptide in published research models.
🧪 Peptide Research Tools: Use QSC’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌏 Shipping: China warehouse — 7–14 day global delivery

Source: PubMed / NCBI  ·  Last 10 years  ·  Refreshed every 24 hours  ·  For research reference only — not clinical guidance.

⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION

QSC products are strictly for in vitro and in vivo laboratory research. Not intended for diagnostic, therapeutic, or personal use.

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Research Use Disclaimer

All QSC products are strictly for laboratory, scientific, and research use only. They are not for human consumption, medical treatment, diagnosis, or disease prevention.

By purchasing or using QSC products, you confirm:

  • You are a qualified researcher or acting under the supervision of one.
  • Products will only be used for legitimate research purposes.
  • Products are not evaluated by the FDA or any regulatory authority for human use.
  • You assume all responsibility for legal compliance, proper handling, and storage.
  • You meet the legal age requirement in your jurisdiction.
No Warranty: Products are sold “as is,” with no express or implied warranties regarding efficacy, safety, or suitability. Results in research may vary. QSC is not responsible for outcomes, interpretations, or conclusions drawn from any studies conducted using these products.
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General Safety & Handling

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Not for Human Use

These compounds are for research only. Any off-label, personal, or clinical use is strictly outside the intended scope of supply.

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PPE Required

Always use appropriate personal protective equipment (gloves, lab coat, eye protection) when handling peptides.

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Storage Compliance

Follow product-specific storage conditions to maintain identity, purity, and biological activity.

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Proper Disposal

Dispose of all materials in accordance with institutional biosafety, chemical waste, and hazardous material protocols.

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Verify Quality

Janoshik COAs are available on every product page. Verify batch identity (MS confirmed) and purity (≥99% HPLC) before use.

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Peptide Storage Guidelines

🌑 Light-protected💧 Low moisture🌡️ Stable temperature🔬 Sterile handling

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