Orexin B 10mg | 10-Vial Kit | Hypocretin-2 High-Dose | OX2R Research

Orexin B 10mg | 10-Vial Kit — Orexin-B (Hypocretin-2) — 28aa linear neuropeptide preferentially activating OX2R over OX1R to regulate sleep-wake transitions and energy homeostasis; studied in arousal and metabolic research. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.

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$350

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SKU: QSC-OREB10-OREXINB-10MG-10VIAL
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QSC RESEARCH GRADE

≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS8-Region Domestic Shipping

What is Orexin B (High-Dose)??

Orexin B (Hypocretin-2, CAS 205640-91-1) is a 28-amino acid OX2R-selective hypothalamic neuropeptide. This 10mg/vial high-dose format supports research protocols requiring larger quantities – dose-escalation OX2R receptor occupancy studies, multi-cohort sleep paradigms, high-throughput competitive binding assays, or extended in vivo infusion experiments investigating OX2R-mediated histaminergic arousal, sleep-wake architecture, or suvorexant mechanism-of-action comparisons. The 10mg format also enables combination assays comparing Orexin B (OX2R-selective) vs. Orexin A (OX1R/OX2R dual) biology side-by-side with adequate quantities for both arms.

Research Applications

High-Dose OX2R Occupancy

Dose-escalation receptor saturation kinetics, Bmax/Kd determination in hypothalamic membrane preparations

Multi-Cohort Sleep Studies

Sufficient for large-animal or multi-arm sleep EEG studies requiring repeated orexin B administration

High-Throughput Receptor Screening

Competitive binding assays – Orexin B as OX2R radioligand competitor against novel antagonist libraries

Suvorexant Mechanism Studies

OX2R occupancy correlation with sleep onset/maintenance – comparison with dual OX1R/OX2R blockade

Comparative Orexin Biology

Orexin A vs. B functional comparison assay – OX1R-specific phenotypes vs. OX2R-specific phenotypes with 10mg of each

Quick Specs

Form Lyophilized powder
Purity >=99% by HPLC – every batch
CAS Number 205640-91-1
Also Known As Hypocretin-2, HCRT2
Sequence Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Receptor Selectivity OX2R-preferring (~5-100x vs. OX1R) – 10mg/vial high-dose
Peptide Type Endogenous 28-aa hypothalamic neuropeptide / OX2R-selective agonist – high dose
Identity MS molecular weight confirmed – every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS – Qingdao, China
Storage -20C sealed | 2-8C reconstituted (2-4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

For the latest Certificate of Analysis (COA), please email us with your request.

Frequently Asked Questions

How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use QSC’s free peptide calculators – reconstitution, BAC water, dosing, half-life, and mixing charts.
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Source: PubMed / NCBI  ·  Last 10 years  ·  Refreshed every 24 hours  ·  For research reference only — not clinical guidance.

⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION

QSC products are strictly for in vitro and in vivo laboratory research. Not intended for diagnostic, therapeutic, or personal use.

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Research Use Disclaimer

All QSC products are strictly for laboratory, scientific, and research use only. They are not for human consumption, medical treatment, diagnosis, or disease prevention.

By purchasing or using QSC products, you confirm:

  • You are a qualified researcher or acting under the supervision of one.
  • Products will only be used for legitimate research purposes.
  • Products are not evaluated by the FDA or any regulatory authority for human use.
  • You assume all responsibility for legal compliance, proper handling, and storage.
  • You meet the legal age requirement in your jurisdiction.
No Warranty: Products are sold “as is,” with no express or implied warranties regarding efficacy, safety, or suitability. Results in research may vary. QSC is not responsible for outcomes, interpretations, or conclusions drawn from any studies conducted using these products.
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General Safety & Handling

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Not for Human Use

These compounds are for research only. Any off-label, personal, or clinical use is strictly outside the intended scope of supply.

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PPE Required

Always use appropriate personal protective equipment (gloves, lab coat, eye protection) when handling peptides.

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Storage Compliance

Follow product-specific storage conditions to maintain identity, purity, and biological activity.

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Proper Disposal

Dispose of all materials in accordance with institutional biosafety, chemical waste, and hazardous material protocols.

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Verify Quality

Janoshik COAs are available on every product page. Verify batch identity (MS confirmed) and purity (≥99% HPLC) before use.

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Peptide Storage Guidelines

🌑 Light-protected💧 Low moisture🌡️ Stable temperature🔬 Sterile handling

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