Botulinum Toxin Type A 100 IU | 1-Vial | SNAP-25 Cleaving Neurotoxin | Neuromuscular & Cosmetic Research

Botulinum Toxin Type A (BoNT-A, CAS 93384-43-1) 100 IU — >=99% HPLC purity, MS confirmed, Janoshik COA. Research use only.

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SKU: QSC-BOTOX-100IU-1VIAL
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≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping

What is Botulinum Toxin Type A??

Botulinum Toxin Type A (BoNT-A, CAS 93384-43-1) is a 150 kDa zinc-dependent metalloprotease produced by Clostridium botulinum. It consists of a 100 kDa heavy chain (receptor binding and membrane translocation) disulfide-linked to a 50 kDa light chain (catalytic endopeptidase). BoNT-A cleaves SNAP-25 (synaptosomal-associated protein 25 kDa) at the presynaptic neuromuscular junction – preventing SNARE complex assembly required for acetylcholine (ACh) vesicle fusion and release. This produces localised chemodenervation lasting 3-6 months until new nerve terminal sprouting restores function. BoNT-A is both the world’s most potent biological toxin and one of the most widely used therapeutics, forming the mechanistic basis for cosmetic wrinkle reduction, spasticity treatment, hyperhidrosis, migraine prophylaxis, and autonomic disorder research.

Research Applications

SNARE Complex & Neuromuscular Biology

SNAP-25 endoproteolysis, SNARE complex inhibition kinetics, ACh vesicle exocytosis blockade mechanisms

Chemodenervation Research

Motor end-plate remodelling, nerve terminal sprouting/recovery, NMJ plasticity timecourse studies

Cosmetic & Dermatology Research

Glabellar/forehead wrinkle reduction mechanisms, mimetic muscle paralysis, collagen remodelling under denervation

Spasticity & Movement Disorders

Upper motor neuron syndrome models, dystonia, cerebral palsy – focal muscle hyperactivity quantification

Autonomic & Pain Research

Hyperhidrosis sweat gland denervation, chronic migraine CGRP pathway interaction, autonomic ganglia studies

Quick Specs

Form Lyophilized powder
Purity >=99% by HPLC – every batch
CAS Number 93384-43-1
Activity 100 IU/vial (1 IU = LD50 in 18-20g female Swiss-Webster mice)
Molecular Weight ~150 kDa (heavy chain + light chain disulfide homodimer)
Mechanism SNAP-25 endoproteolysis – SNARE complex inhibition – ACh vesicle blockade
Peptide Type Bacterial zinc-dependent metalloprotease / neurotoxin serotype A
Identity MS molecular weight confirmed – every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS – Qingdao, China
Storage -20C sealed | Do NOT reconstitute until use
Shelf Life 24 months unopened

Certificate of Analysis (COA)

For the latest Certificate of Analysis (COA), please email us with your request.
Peptide Research Tools: Use QSC’s free peptide calculators – reconstitution, BAC water, dosing, half-life, and mixing charts.
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Source: PubMed / NCBI  ·  Last 10 years  ·  Refreshed every 24 hours  ·  For research reference only — not clinical guidance.

⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION

QSC products are strictly for in vitro and in vivo laboratory research. Not intended for diagnostic, therapeutic, or personal use.

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Research Use Disclaimer

All QSC products are strictly for laboratory, scientific, and research use only. They are not for human consumption, medical treatment, diagnosis, or disease prevention.

By purchasing or using QSC products, you confirm:

  • You are a qualified researcher or acting under the supervision of one.
  • Products will only be used for legitimate research purposes.
  • Products are not evaluated by the FDA or any regulatory authority for human use.
  • You assume all responsibility for legal compliance, proper handling, and storage.
  • You meet the legal age requirement in your jurisdiction.
No Warranty: Products are sold “as is,” with no express or implied warranties regarding efficacy, safety, or suitability. Results in research may vary. QSC is not responsible for outcomes, interpretations, or conclusions drawn from any studies conducted using these products.
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General Safety & Handling

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Not for Human Use

These compounds are for research only. Any off-label, personal, or clinical use is strictly outside the intended scope of supply.

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PPE Required

Always use appropriate personal protective equipment (gloves, lab coat, eye protection) when handling peptides.

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Storage Compliance

Follow product-specific storage conditions to maintain identity, purity, and biological activity.

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Proper Disposal

Dispose of all materials in accordance with institutional biosafety, chemical waste, and hazardous material protocols.

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Verify Quality

Janoshik COAs are available on every product page. Verify batch identity (MS confirmed) and purity (≥99% HPLC) before use.

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Peptide Storage Guidelines

🌑 Light-protected💧 Low moisture🌡️ Stable temperature🔬 Sterile handling

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