QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is MOTS-c (High-Dose)??
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c, CAS 1457483-14-9) is a 16-amino acid mitochondria-derived peptide that activates AMPK, drives GLUT4-mediated glucose uptake, and modulates the FOXO longevity pathway. This 30mg high-dose vial supports dose-escalation studies, concentration-response profiling, and multi-arm metabolic experiments requiring higher peptide quantities — including in vivo obesity, type 2 diabetes, and exercise-ageing interaction models where sustained MOTS-c exposure is investigated.
Research Applications
High-Dose AMPK Studies
Dose-escalation AMPK activation kinetics, concentration-dependent GLUT4 translocation
Obesity & T2DM Models
High-dose metabolic reversal in diet-induced obesity, pancreatic β-cell studies
Exercise-Mimetic Research
MOTS-c as exercise-mimetic factor — muscle and liver substrate metabolism without exercise
Mitochondrial Stress Response
High-dose mito-nuclear retrograde communication, mtROS response, stress-adaptive pathways
Longevity Pathway Profiling
FOXO3, SIRT1, PGC-1α, and mTOR interaction at supraphysiological MOTS-c concentrations
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 1457483-14-9 |
| Molecular Formula | C₉₄H₁₄₆N₂₈O₂₄S₂ |
| Molecular Weight | 2174.5 g/mol |
| Peptide Type | Mitochondria-derived peptide (MDP) / AMPK activator — high dose |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
